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A meta-analysis conducted by Chen et al., consisting of 13 controlled clinical trials with 3512 participants, showed better efficacy of tailored therapies compared with empirically chosen regimens (Chen et al

Emerging evidence now links dysregulated mTOR signaling and impaired autophagy to G2/M arrest in aged tubular cells, exacerbating senescence and fibrosis (O'Sullivan et al., 2022)

54 A recent study demonstrated that cross-talk between necroptosis and the NLRP3 inflammasome promotes APAP-induced liver injury

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ROS exacerbate the severity of asthma symptoms by activating inflammatory mediators that cause airway smooth muscle contraction, promote mucus hypersecretion, increase the permeability of lung capillaries, and damage cell membranes

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